Simeprevir concentration is increased by approximately 6-fold when coadministered with cyclosporine (in combination with daclatasvir [an investigational drug] and RBV). Coadministration of simeprevir with cyclosporine is not recommended. For more information see Unique Patient Populations.
What’s New and Updates/Changes
We are pleased to introduce the newest section of the Guidance, When and in Whom to Initiate HCV Therapy. Successful hepatitis C treatment results in sustained virologic response (SVR), which is tantamount to virologic cure; virologic cure is expected to benefit chronically infected persons.
View Official Press Release: When and In Whom to Initiate HCV Therapy Now Available at www.HCVguidelines.org
How to cite the Guidance in papers
The website as a whole.
AASLD-IDSA. Recommendations for testing, managing, and treating hepatitis C. http://www.hcvguidelines.org. $$$Insert date accessed here$$$.
A section or specific page on the website.
For example, if citing the HCV Testing and Linkage to Care section:
AASLD-IDSA. HCV testing and linkage to care. Recommendations for testing, managing, and treating hepatitis C. http://www.hcvguidelines.org/full-report/hcv-testing-and-linkage-care. $$$Insert date accessed here$$$.
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Notable changes are highlighted in yellow for approximately 1 month.
Retreatment Box (Summary). Recommendations for Patients in Whom Previous PEG/RBV Treatment Has Failed
For patients with genotype 1 HCV and prior PEG/RBV failure the treatment duration of PEG/RBV in the alternate regimen SMV/PEG/RBV has been corrected to 48 weeks; for patients with genotype 4 HCV and prior PEG/RBV failure, SOF +RBV x 24 weeks was corrected to be listed as an alternative regimen and SMV/ PEG/RBV was removed as an alternative; for patients with genotype 5 or 6 HCV the incorrect listing of SOF/RBV as an alternative regimen was removed.
For patients with prior PEG/RBV/HCV protease inhibitor failure, this portion of the box was reformatted for clarity and alternative regimens by IFN eligibility have been listed.
Retreatment of Persons in Whom Prior Therapy Has Failed
1, Genotype 1. The recommended regimen for prior failures of PEG/RBV/HCV protease inhibitor regimens was added for clarity; the alternative regimen; the alternative regimen (and supporting text) for IFN ineligible patients was added.
Unique Patient Populations: HIV/HCV Coinfection Summary
Tipranavir (as described in the text) was added to the table of not allowable with SOF use.