Recommended and alternative regimens listed by evidence level and alphabetically for:
Sofosbuvir-Based Treatment Failures, With or Without Compensated Cirrhosisa
|
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|---|---|---|
| RECOMMENDED | DURATION |
RATING 
|
|
Daily fixed-dose combination of sofosbuvir (400 mg)/velpatasvir (100 mg)/voxilaprevir (100 mg)b |
12 weeks | I, A |
| ALTERNATIVE | DURATION |
RATING
|
|
Daily fixed-dose combination of glecaprevir (300 mg)/pibrentasvir (120 mg) except for NS3/4 protease inhibitor inclusive combination DAA regimen failuresc
|
16 weeks | I, A |
|
a For decompensated cirrhosis, please refer to the appropriate section. b Genotype 3: Add weight-based ribavirin if cirrhosis is present and there are no contraindications. c This regimen is not recommended for patients with prior exposure to an NS5A inhibitor plus NS3/4 PI regimens (e.g., elbasvir/grazoprevir). |
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