This version of the guidance has been updated to reflect several important developments in the identification and management of chronic hepatitis C. All treatment sections have been updated; less efficacious, complex, alternative regimens and those no longer available in the U.S. have been removed.

• Initial Treatment of HCV Infection: Shortened G/P regimen for use in compensated cirrhosis
• New Simplified HCV Treatment for Treatment-naive Patients Without Cirrhosis
• Retreatment of Persons in Whom Prior Therapy Failed: Update on SOF/VEL/VOX and G/P failures
• HCV Testing and Linkage to Care: Universal screening for adults
• HCV in Children: New treatment regimens for children aged 3 to 11 years
• Management of Acute HCV Infection: New recommendation for initiating treatment without waiting period
• Kidney Transplant Patients: Updated treatment recommendations
• Liver Transplantation: New information about transplantation of organs from HCV-infected donors
   

Updated references have been provided throughout the guidance where appropriate.