Summary: Treatment-Naive Genotype 5 or 6
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Recommended and alternative regimens listed by pangenotypic, evidence level and alphabetically for:
Treatment-Naive Genotype 5 or 6 Patients With and Without Compensated Cirrhosisa 
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RECOMMENDED
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DURATION
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RATING 
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Daily fixed-dose combination of glecaprevir (300 mg)/pibrentasvir (120 mg)b
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8 weeks
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I, Ac
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Daily fixed-dose combination of sofosbuvir (400 mg)/velpatasvir (100 mg)
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12 weeks
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I, B
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Daily fixed-dose combination of ledipasvir (90 mg)/sofosbuvir (400 mg)d
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12 weeks
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IIa, B
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a For decompensated cirrhosis, please refer to the appropriate section.
b Dosing is 3 coformulated tablets (glecaprevir [100 mg]/pibrentasvir [40 mg]) taken once daily. Please refer to the prescribing information.
c For compensated cirrhosis, rating is I, B.
d Not recommended for genotype 6e if subtype is known.
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